解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Crocin is a pharmacologically active component of Crocus sativus. It is an unusual water-soluble carotenoid responsible for the red color of saffron. In various studies, the anticancer effect of saffron and its constituents has been established. Polyethylene glycolated nanoliposomes with a size range up to 200 nm are ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328363
更新日期:2013-04-01 00:00:00
abstract::The phenylpropanoid dibenzylbutyrolactone lignan arctigenin, a key component found in Arctium lappa, or burdock, has been reported with a variety of therapeutic effects including anticancer, anti-inflammation, and antivirus effects. Using LC/MS/MS, three novel metabolites of arctigenin, namely, arctigenic acid, arctig...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328332
更新日期:2013-04-01 00:00:00
abstract::A study of secondary metabolites from the bark of Alnus glutinosa led to the isolation of fourteen diarylheptanoids: oregonin (1), platyphylloside (2), rubranoside A (3), rubranoside B (4), hirsutanonol (5), hirsutenone (6), hirsutanonol-5-O-β-D-glucopyranoside (7), platyphyllonol-5-O-β-D-xylopyranoside (8), aceroside...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328301
更新日期:2013-04-01 00:00:00
abstract::Airway remodeling is an important characteristic of asthma, linking inflammation with airway hyperresponsiveness. Baicalin, a major active component, was isolated from Radix Scutellariae. Many studies show that baicalin has anti-inflammatory, anti-bacterial, and anti-allergic effects. Here we investigate the influence...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328197
更新日期:2013-03-01 00:00:00
abstract::In the course of our investigations on Umutambasha in order to identify its convulsant principles, small quantities of monofluoroacetate were observed in stem bark, leaves, and fruits of this plant newly identified as Dichapetalum michelsonii Hauman. Conclusive evidence for a monofluoroacetate presence came from its i...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328283
更新日期:2013-03-01 00:00:00
abstract::Ten new nervogenic acid derivatives (1-4, 6-11) and one known compound (5) have been isolated from Liparis nervosa. Their structures were determined using extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 3, 4, 9, 10, and 11 were evaluated for their cytotoxicity against A549, H460, Hela,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328109
更新日期:2013-03-01 00:00:00
abstract::Blood fluke of the genus Schistosoma are the etiological agents of human schistosomiasis, an important neglected tropical disease that afflicts over 200 million people worldwide. The treatment for this disease relies heavily on a single drug, praziquantel. Recent reports of praziquantel resistance raise concerns about...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328173
更新日期:2013-03-01 00:00:00
abstract::An Alkanna orientalis leaf and flower extract inhibited the growth of Staphylococcus aureus, a pathogen that causes an estimated 478 000 hospitalizations in the US annually. Bioassay-guided fractionation of A. orientalis resulted in isolation of the flavonoid sarothrin (5,7,4'-trihydroxy-3,6,8-trimethoxyflavone), whic...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328259
更新日期:2013-03-01 00:00:00
abstract::Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328069
更新日期:2013-01-01 00:00:00
abstract::Two new C-benzylated dihydrochalcone derivatives, 4,2',4'-trihydroxy-6'-methoxy-3'(2''-hydroxybenzyl)dihydrochalcone (1) and 2',4'-dihydroxy-4,6'-dimethoxy-3'(2''-hydroxybenzyl)dihydrochalcone (2), along with six known flavonoid derivatives (3-8), a known dihydrochalcone dimer (9), three known aromatic esters (10-12),...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1327950
更新日期:2013-01-01 00:00:00
abstract::In this study, hemolysis, Western blot, and real-time RT-PCR assays were performed to evaluate silibinin's activity against S. aureus α-toxin secretion. In addition, live/dead cell staining and lactate dehydrogenase activity assays were introduced to examine the influence of silibinin on α-toxin-induced cell injury in...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328068
更新日期:2013-01-01 00:00:00
abstract::Juniperus excelsa fruit essential oil as well as J. oxycedrus, Cedrus libani, and Pinus pinea wood essential oils have been obtained with yields between 2.2 ± 0.3 % to 3.4 ± 0.5 % and analyzed by gas chromatography. Sesquiterpenes mainly characterized C. libani and J. oxycedrus essential oils, while in P. pinea and J....
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0032-1327896
更新日期:2012-12-01 00:00:00
abstract::Capsaicin and 6-gingerol, pungent components of chilli pepper and ginger, are known as dietary agonists of transient receptor potential vanilloid-1. Transient receptor potential vanilloid-1 nerve fibers are recognized to play a role in gastric mucosal integrity in rats. In the present studies, we examined the acute ef...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315387
更新日期:2012-11-01 00:00:00
abstract::The purpose of this study was to investigate dermal pharmacokinetics of terpinen-4-ol in rats following topical administration of plai oil derived from the rhizomes of Zingiber cassumunar Roxb. Unbound terpinen-4-ol concentrations in dermal tissue were measured by microdialysis. The dermal pharmacokinetic study of ter...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315262
更新日期:2012-11-01 00:00:00
abstract::Despite the huge diversity of antibacterial compounds, bacterial resistance to first-choice antibiotics has been drastically increasing. Moreover, the association between multiresistant microorganisms and nosocomial infections highlight the problem, and the urgent need for solutions. Natural resources have been exploi...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1315370
更新日期:2012-11-01 00:00:00
abstract::A museum collection of Cinchonae cortex samples (n = 117), from the period 1850-1950, was extracted with a mixture of chloroform-d1, methanol-d4, water-d2, and perchloric acid in the ratios 5 : 5 : 1 : 1. The extracts were directly analyzed using 1H NMR spectroscopy (600 MHz) and the spectra evaluated using principal ...
journal_title:Planta medica
pub_type: 历史文章,杂志文章
doi:10.1055/s-0032-1315396
更新日期:2012-11-01 00:00:00
abstract::Three new azaphilones, chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3), and two new chlorinated phenolic glycosides, globosumoside A (4) and globosumoside B (5), were isolated from the crude extract of the fungal strain Chaetomium elatum No. 89-1-3-1. Their structures were determin...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315211
更新日期:2012-10-01 00:00:00
abstract::Two new heliangolides, incomptines C (3) and D (4), were isolated from the leaves of Decachaeta incompta. The structures were established by spectroscopic methods and confirmed by X-ray crystallography. The antiprotozoal activity of incomptines C and D was evaluated. Additionally, the chromatographic profile of the le...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315255
更新日期:2012-10-01 00:00:00
abstract::This study was carried out to examine the potential beneficial effect of cordycepin on the decline of testicular function induced with age. A total of 30 male Sprague-Dawley rats (twenty-four 12-month-olds and six 2-month-olds) were divided into five groups. The young control (YC) and middle-aged control (MC) groups r...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315212
更新日期:2012-10-01 00:00:00
abstract::In this study we investigate the active constituents of the rhizome of Zingiber officinale, Roscoe (ginger) and determine their activity on glucose uptake in cultured L6 myotubes and the molecular mechanism underlying this action. Freeze-dried ginger powder was extracted with ethyl acetate (1 kg/3 L) to give the total...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315041
更新日期:2012-09-01 00:00:00
abstract::Constitutively activated STAT3 plays a pivotal role in oncogenesis and metastasis in many human cancers, and STAT3 has been validated as a novel anticancer drug target. Thus, the identification of small molecules that modulate STAT3 activity could be of great therapeutic importance. The aim of this study was to isolat...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315121
更新日期:2012-09-01 00:00:00
abstract::Five new xanthone glycosides, comastomasides A-E (1-5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1-5 were evaluated for their hepatoprotective activity and cytotoxicity ag...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315079
更新日期:2012-09-01 00:00:00
abstract::In the present study, we examined the effects of deoxyschisandrin (DS) from Schisandra chinensis on the amyloid-beta₁₋₄₂ (Aβ₁₋₄₂)-induced memory impairment in mice and investigated the possible antioxidative mechanism. Mice were given an intracerebroventricular (i. c. v.) injection with the aggregated Aβ₁₋₄₂ and then ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315019
更新日期:2012-08-01 00:00:00
abstract::A methanol extract of the leaves of Syzygium polyanthum (Wight) Walp. afforded four new acylbenzene derivatives (1-4) together with seven known compounds (5-11). The structures of 1-11 were elucidated by extensive spectroscopic methods and comparison with the literature data. The new compounds 1-3 and a known compound...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315000
更新日期:2012-08-01 00:00:00
abstract::Fresh Nagami kumquats (Fortunella margarita) were subjected to hydrodistillation using a Clevenger-type apparatus to obtain volatile oil. The chemical composition of the volatile oil was analyzed by GC-MS using Rtx-5 Sil MS and DB Wax columns. A total of 25 volatile compounds were identified by mass spectra, retention...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298619
更新日期:2012-06-01 00:00:00
abstract::Agastache mexicana is a plant in high demand that has long been used in Mexican folk medicine to treat anxiety, insomnia, and stomachache, among other afflictions. Ursolic acid and acacetin were isolated and identified as two possible active compounds of A. mexicana aerial parts. An antinociceptive response was demons...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298416
更新日期:2012-05-01 00:00:00
abstract::A phytochemical investigation of the whole plants of Cassia occidentalis led to the isolation of two new cycloartane triterpenoids, cycloccidentalic acids A and B (1 and 2), and five new related saponins, cycloccidentalisides I-V (3-7), together with sixteen known compounds. The structures of the isolated compounds we...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298376
更新日期:2012-05-01 00:00:00
abstract::The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main meta"bolite arctigenin was identified by an LC-MS method, and an HPLC-UV technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. Chromatograp...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298433
更新日期:2012-05-01 00:00:00
abstract::Khat (Catha edulis Forsk.) is a perennial shrub whose young leaves are chewed for their psychostimulating and anorectic properties. The main active principles of khat are believed to be the phenylpropylamino alkaloids, primarily (-)-cathinone [(S)-α-aminopropiophenone], (+)-cathine [(1S)(2S)-norpseudoephedrine], and (...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298430
更新日期:2012-05-01 00:00:00
abstract::In natural product chemistry, it is often crucial to determine sugar composition as well as the absolute configuration of each monosaccharide in glycosides. An ultra-performance liquid chromatography method using both photodiode array (PDA) and mass spectrometry detectors (UPLC-UV/MS) was developed for qualitative ana...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298432
更新日期:2012-05-01 00:00:00
abstract::Geniposide, a main iridoid glucoside component of gardenia fruit, has been shown to possess anti-inflammatory activity. However, its potential use for acute lung injury (ALI) has not yet been studied. The aim of this study was to evaluate the anti-inflammatory properties of geniposide using a mouse ALI model. ALI was ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298212
更新日期:2012-04-01 00:00:00
abstract::From the stem bark of Strychnos malacoclados, one new bisindole alkaloid, 3-hydroxylongicaudatine Y (1), was isolated along with the known alkaloids vomicine (2), bisnordihydrotoxiferine (3), divarine (4), longicaudatine (5), longicaudatine Y (6), and longicaudatine F (7). All the compounds were tested for their antim...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280473
更新日期:2012-03-01 00:00:00
abstract::The gamma-amino butyric acid (GABA) type A (GABA(A)) receptor represents a crucial target for clinical agents in the treatment of anxiety and insomnia. Using the two-microelectrode voltage clamp technique on recombinant α₁β₂γ(2S) GABA (A) receptors, effusol (1) and dehydroeffusol (2) were isolated in a bioactivity-gui...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298174
更新日期:2012-03-01 00:00:00
abstract::The ripe berries of Harrisonia abyssinica yielded two new prenylated acetophenones, namely 5-(ethan-1'''-one)-4,6-dihydroxy-7-(3'',3''-dimethylallyl)-2 S-(1' S-hydroxy-1',5'-dimethylhex-4'-enyl)-2,3-dihydrobenzofuran (1) and 5-(2'''-hydroxyethan-1'''-one)-4,6-dihydroxy-7-(3'',3''-dimethylallyl)-2 S-(1' S-hydroxy-1',5'...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0031-1298143
更新日期:2012-03-01 00:00:00
abstract::The therapy of type-2 diabetes mellitus is one of the major challenges of our age. A possible strategy to prevent the progression of this disease is the inhibition of protein tyrosine phosphatase 1B (PTP1B), a major negative regulator in the insulin and leptin signalling pathway. Phellodendri amurensis cortex is a wel...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280377
更新日期:2012-02-01 00:00:00
abstract::Six new triterpenoids including four new secodammarane triterpenoid glycosides (1-4), an epoxydammarane triterpenoid glycoside (5), and a new secodammarane triterpenoid (6) were isolated from the ethanolic extract of the leaves of Cyclocarya paliurus. The structures of these compounds were elucidated by spectroscopic ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280411
更新日期:2012-02-01 00:00:00
abstract::Two new lactones, 1 and 2, together with five known compounds, 3-7, were isolated from the marine mangrove fungus Xylaria sp. BL321. Their structures were determined by comprehensive analysis of their MS and NMR spectroscopic data. The absolute configurations of 1 and 2 were established on the basis of electronic circ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0031-1280347
更新日期:2012-01-01 00:00:00
abstract::A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibit...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280294
更新日期:2012-01-01 00:00:00
abstract::Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280266
更新日期:2012-01-01 00:00:00
abstract::Two new sesquiterpenes, (E)-(2S,3S,6R)-atlantone-2,3-diol (1) and (E)-(2S,3S,6S)-atlantone-2,3,6-triol (2), along with two known sesquiterpenes, atlantolone (3) and (E)-α-atlantone (4), were isolated from Cedrus deodara Loud. The structures of the new compounds were elucidated on the basis of UV, IR, NMR, HR‑ESI-QTOF‑...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0031-1280264
更新日期:2012-01-01 00:00:00